Dutasteride Rx
Dutasteride addresses hair loss by inhibiting 5-alpha-reductase, an enzyme converting testosterone into dihydrotestosterone (DHT), implicated in the miniaturization of hair follicles seen in androgenetic alopecia (male pattern baldness). This gradual process results in smaller follicles producing thinner and shorter hair, eventually leading to the cessation of growth in affected follicles.
Strength
What is Dutasteride?
Dutasteride addresses hair loss by inhibiting 5-alpha-reductase, an enzyme converting testosterone into dihydrotestosterone (DHT), implicated in the miniaturization of hair follicles seen in androgenetic alopecia (male pattern baldness). This gradual process results in smaller follicles producing thinner and shorter hair, eventually leading to the cessation of growth in affected follicles.
What is DHT?
Dihydrotestosterone (DHT) is a derivative of testosterone, a male sex hormone. It is formed when the enzyme 5-alpha-reductase converts testosterone into DHT. While DHT plays a role in various physiological processes, including the development of male characteristics during puberty, it is also implicated in the miniaturization of hair follicles in certain individuals, leading to hair loss.
How does Dutasteride compare to Finasteride?
There is a recent review of clinical trials published in peer-reviewed journals that shows dutasteride to be a more powerful treatment than finasteride for androgenetic alopecia (male pattern baldness). This conclusion was based on a detailed statistical analysis of previously published studies that met certain inclusion criteria. The review concluded that based on this evidence, clinical experience, and anecdotal reports, it is almost certain that dutasteride will provide superior hair growth results compared to finasteride.
Learn more about Finasteride →
Studies
Journal of clinical & experimental dermatology researchTitle: Combination therapy with oral minoxidil and dutasteride in the treatment of male patterned baldness: A case report
Key Takeaways
A combination therapy with oral minoxidil, 2.5 mg/day, and dutasteride, 0.5 mg alternate day was found to produce quick results in male patterned baldness of advanced grades with minimal adverse effects.Department of Dermatology, Inha University College of Medicine, Incheon, Korea.Title: Long-Term Effectiveness and Safety of Dutasteride versus Finasteride
Key Takeaways
Dutasteride-treated patients were older (p<0.001) and more likely to have moderate/severe BASP classification at baseline (p=0.010) compared with finasteride-treated patients.Among patients treated with recommended, on-label dosing exclusively, dutasteride-treated patients showed greater improvement in hair growth than finasteride-treated patientsAmong this same subset, overall occurrence of adverse events (AEs) during the observation period were not statistically equivalent between groupsAdditional Links & Studies
The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia
Finasteride and Dutasteride for the Treatment of Male Androgenetic Alopecia: A Review of Efficacy and Reproductive Adverse Effects
Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor
The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride
Superiority of dutasteride over finasteride in hair regrowth and reversal of miniaturization in men with androgenetic alopecia: A randomized controlled open-label, evaluator-blinded study
Changes in hair weight and hair count in men with androgenetic alopecia after treatment with finasteride, 1 mg, daily
Effect of the 5α-reductase enzyme inhibitor dutasteride in the brain of intact and parkinsonian mice
How ulo works
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Meet the Team
Hair Loss Medical Advisors
William Rassman
MD, Founder of the New Hair Institute (NHI)
Heidi Goodarzi, M.D.
Medical, Surgical, and Cosmetic Dermatologist
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